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Cooley G. Pantazis MD, Kimberly Templeton MD, Ossama W. Tawfik MD, PhD, Raul Braylan MD
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ABSTRACT: We report an unusual case of Langerhans cell granulomatosis (LCG) manifested as a villous synovial proliferation in a 38-year-old female jogger. One year after the onset of joint symptoms, she had a classical LCG presentation with skin and visceral lymph node involvement. Review of the literature revealed only one case of synovial shoulder joint tenosynovitis associated with LCG in a middle-aged woman. Ours is the first reported case presenting clinically in the synovium of the hip joint as pigmented villonodular synovitis. Histiocytic/dendritic proliferations involving the synovial tissues are not uncommon.
These lesions as well as the rare multicentric reticulohistiocytosis (MRH), a systemic monocytoid/ histiocytic disorder with multinucleated giant cells, polyarthritis, and papulonodular skin lesions, should be considered in the differential diagnosis. Clinical and pathologic features will distinguish LCG from MRH
Cooley G. Pantazis MD, Kimberly Templeton MD, Ossama W. Tawfik MD, PhD, Raul Braylan MD
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