Use of Bone Morphogenetic Protein-2 (rh-BMP-2) in Treatment of Wrist and Hand Nonunion With Comparison to Historical Control Groups

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The purpose of this study is to report the percentage of patients achieving union, time to union, and complications with the use of bone morphogenetic protein-2 (rh-BMP-2) in surgical repair of established nonunion in the hand and wrist. Twenty-seven patients with nonunion of the hand and wrist were treated between 2005 and 2011 with surgical repair and augmentation using 4.2 mg of rh-BMP-2.  Sites of nonunion included the phalanx (seven), carpus (nine), distal radius (five), and distal ulna (six).  Radiographic union and complications were the primary and secondary outcomes, respectively. Eightynine percent (24/27) of patients achieved union within an average of 4.3 š 2.8 months of surgery. There were no direct complications from administration of rh-BMP-2. Radiographic union was consistent with published rates for nonunion repair of scaphoid, phalanx, and distal radius fractures. Rh-BMP-2 did not produce superior rates of union in the patients with wrist and hand nonunion.

SKU: JSOA-2013-22-4-W2 Categories: , Tags: , , ,

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Ian Rice, MD, and John D. Lubahn, MD

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