Evaluation of a Single-Dose, Extended-Release Epidural Morphine Formulation for Pain Control After Lumbar Spine Surgery


DepoDur, an extended-release epidural morphine, has been used effectively for postoperative pain control following many orthopaedic and general surgery procedures and has provided prolonged analgesia when compared with Duramorph. The goal of this article was to compare the safety and analgesic efficacy of DepoDur versus Duramorph after lumbar spine surgery. A prospective, randomized, double-blind clinical study was completed at a single extended-stay ambulatory surgery center. All patients over 18 undergoing posterior lumbar spine fusions were considered for the study. Sixty patients were randomly assigned to a control or treatment group. The control group received DepoDur before surgery, while the treatment group received Duramorph. Although results show no significant differences between the two groups in postoperative visual analog pain scale scores, use of pain medication, and adverse events, subjects receiving DepoDur were less likely to receive Naloxone and oxygen supplementation, experience nausea or fever, and were more likely to experience hypotension. DepoDur proved to be safe and effective, offering similar prolonged analgesic activity when compared with Duramorph. (Journal of Surgical Orthopaedic Advances 23(1):9–12, 2014)

Key words: analgesic, DepoDur, Duramorph, epidural morphine

SKU: JSOA-2014-23-1-W2 Categories: , Tags: , , ,

Joseph C. Vineyard, MD; John S. Toohey, MD; Arvo Neidre, MD; Guy Fogel, MD; and Robert Joyner, MD