Musculoskeletal Manifestations of Amyloidosis: A Focused Review - Thomas X. Nguyen, MD; Abbas Naqvi, MD; Terry L. Thompson, MD; and Robert H. Wilson, MD

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Amyloidosis is a poorly understood condition that can wreak havoc on numerous systems within the human body. In addition, this disease can present in multiple forms which each have their own unique physiology and subsequent effects. However, while the literature on the etiology and effect of amyloidosis on various organ systems is numerous, few have highlighted the musculoskeletal manifestations of this devastating disease. This review focuses on the recent research on amyloid deposition in the musculoskeletal system. Additionally, risk factors, classification, differential diagnoses, indications for biopsy, and manifestations of amyloidosis in the musculoskeletal system as well as in other tissues are discussed. Furthermore, the surgical and nonsurgical approaches to treatment are covered. (Journal of Surgical Orthopaedic Advances 27(1):1–5, 2018) Key words: amyloid light chain (AL) amyloidosis, amyloidoma, beta 2-microglobulin (Aβ2M) amyloidosis, musculoskeletal manifestations, transthyretin (ATTR) amyloidosis, systemic amyloid A (AA) amyloidosis

Midterm Follow-up of Divergent Peg Glenoid Components in Total Shoulder Arthroplasty - Thomas W. Wright, MD; Tony L. Bryant, MD; Christopher G. Stevens, MD; Brett C. Bentley, MD; and Kevin W. Farmer, MD

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Glenoid component aseptic loosening is the most common source of total shoulder arthroplasty (TSA) revision. Divergent pegged glenoids may improve fixation. Thirty-four patients underwent divergent peg TSA. Data were reviewed for component loosening. Failure was defined as the need for revision after loosening. The last postoperative radiographs were graded on a Lazarus glenoid lucency scale. Mean follow-up was 5.6 years š 2.44 (range, 2–10 years). Radiolucency around one or fewer pegs was noted in 14/20 patients. Six glenoids had complete radiolucency around two pegs; one shoulder had gross loosening. No secondary surgery was performed. Improvements were seen in active elevation and internal rotation. The mean Shoulder Pain and Disability Index (SPADI) score decreased by 48.1 points (p D .039). Shoulder elevation, internal rotation, and SPADI scores significantly improved at final follow-up. No patients underwent revision for glenoid loosening. There were, however, a significant number of patients with radiolucency around two pegs. (Journal of Surgical Orthopaedic Advances 27(1):6–9, 2018) Key words: divergent peg, glenoid component, loosening, revision, total shoulder arthroplasty

Behavioral Economics and Physician Board Meetings: Opportunity Cost, Regret, and Their Mitigation in Orthopaedic Surgery - Brent J. Sinicrope, MD; Craig S. Roberts, MD, MBA; and Lyle Sussman, PhD

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Health care is a business. Health care providers must become familiar with terms such as opportunity costs, the potential loss or gain when one choice is made in lieu of another. The purpose of this study was to calculate the opportunity cost of two orthopaedic surgery society board meetings and discuss these in the context of behavioral economics and regret. A literature search was conducted to determine an orthopaedic surgeon’s average yearly salary, hours worked per week, and weeks worked per year. The details of two orthopaedic surgery professional society meetings that one senior author (CSR) attended were used to calculate opportunity cost. Although the true benefits are multifactorial and difficult to objectively quantify, awareness of the cost–benefit ratio can help guide time and resource management to maximize the return on investment while minimizing buyer’s remorse and perhaps influence the media by which medical meetings are held in the future. (Journal of Surgical Orthopaedic Advances 27(1):10–13, 2018) Key words: behavioral economics, buyer’s regret, opportunity cost

Surgical Complications Associated With Atypical Femur Fractures Attributed to Bisphosphonate Use - Douglas S. Schultz, MD; Henry M. Gass IV, MD; William R. Barfield, PhD; Harry A. Demos, MD; and Langdon A. Hartsock, MD

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Complications of atypical femur fractures (AFFs) are common. AFFs often receive the same treatment as other femoral fractures; however, there appears to be a higher rate of adverse outcomes. Nine patients sustained a total of 13 AFFs, had documented bisphosphonate use before fracture, and had surgery between 2006 and 2012. Complications included continued pain, surgical revision, nonunion, malunion, deformity, or heterotopic ossification. The overall complication rate was 33.3%, with four of the 12 surgeries performed at this institution resulting in one nonunion and three minor complications. None of the primary fixations required revision. There was a higher complication rate for AFFs when compared with non-bisphosphonate-related intramedullary nail femur fracture fixations. This cohort demonstrated a lower rate of major complications compared to the literature. Using a reamed, statically locked nail, halting bisphosphonate medication, and allowing early weight bearing is a safe and efficacious method to treat atypical femur fractures. (Journal of Surgical Orthopaedic Advances 27(1):14–20, 2018) Key words: atypical femur fracture, bisphosphonate medication

Direct Anterior Approach Has Lower Deep Infection Frequency Than Less Invasive Direct Lateral Approach in Primary Total Hip Arthroplasty - Sean A. Sutphen, DO; Keith R. Berend, MD; Michael J. Morris, MD; and Adolph V. Lombardi, Jr., MD, FACS

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Debate continues over the direct anterior (DA) approach. The purpose of this study is to compare the frequency of deep infection between a DA approach and a less invasive direct lateral (LIDL) approach in a large consecutive series of primary total hip arthroplasty (THA). The authors identified 5702 primary THAs performed between 2007 and 2014. DA approach was used in 3540 hips and LIDL in 2162. Patient records were reviewed. Statistical analysis of reoperation, infection- or wound-related complication, and deep infection was performed. During the 8-year follow-up period, there were 98 reoperations in the DA group (2.8%) and 77 in the LIDL group (3.6%; p D .09 NS). Wound- or infection-related reoperation occurred in 32 DA THAs (0.9%) versus 36 LIDL THAs (1.7%; p D .01). Deep infection occurred in 7 DA THAs (0.2%) versus 21 LIDL THAs (0.97%; p < .0001). The risk of deep infection was statistically lower in the DA approach. (Journal of Surgical Orthopaedic Advances 27(1):21–24, 2018) Key words: direct anterior approach, infection, surgical technique, total hip arthroplasty

Lumbar Discography Is Associated With Poor Return to Work Status Following Lumbar Fusion Surgery in a Workers’ Compensation Setting - Joshua T. Anderson, BS; Jeffrey A. O’Donnell, BS; Arnold R. Haas, BS, BA; Rick Percy, PhD; Stephen T. Woods, MD; Uri M. Ahn, MD; and Nicholas U. Ahn, MD

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Lumbar discography (LD) is used to guide surgical decision making in patients with degenerative disc disease (DDD). Its safety and diagnostic accuracy are under contention. This study evaluates LD’s efficacy within the workers’ compensation (WC) population. Multivariate logistic regression analysis was used to determine the impact that undergoing LD before lumbar fusion for DDD had on return to work (RTW) rates among 1407 WC subjects. Discography was negatively associated with RTW status (p D .042; OR 0.76); 22.2% (142/641) of LD subjects met the RTW criteria, compared with 29.6% (227/766) of controls. Additional preoperative risk factors included psychological comorbidity (p < .001; OR 0.34), age greater than 50 (p < .005; OR 0.64), male gender (p < .037; OR 0.75), chronic opioid use (p < .001; OR 0.53), legal representation (p < .034; OR 0.72), and fusion technique (p < .043). LD subjects used postoperative narcotics for an average of 123 additional days (p < .001). This raises concerns regarding the utility of discography in the WC population. (Journal of Surgical Orthopaedic Advances 27(1):25–32, 2018) Key words: degenerative disk disease, low back pain, lumbar discography, lumbar fusion, return to work, workers' compensation

Cervicothoracic Pedicle Morphometry: Using an Osteological Collection to Characterize Trends in Pedicle Size - Mhamad Faour, MD1; Charles C. Yu, MD; Navkirat Bajwa, MD; Jason O. Toy, MS; Uri M. Ahn, MD; and Nicholas U. Ahn, MD

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Pedicle screws are a common treatment option for spinal instability. Despite their popularity, pedicle screws carry the risk of transpedicular violation with subsequent neural and vascular damage. This study measured the pedicle dimensions of 500 dry specimens in an osteological collection. The data provide the orthopedic spine surgeon with an accurate measure of pedicle morphometry in light of previously limited and contradictory results. The study demonstrates that pedicle height at the cervicothoracic junction tends to increase with body height, particularly for females. Additionally, T1 pedicle width is smaller for females than males and, for males, tends to decrease with increasing body weight. These results are valuable to the spine surgeon because they suggest that taller patients may afford a larger margin for error in the vertical plane. However, they also demonstrate that heavier patients do not have wider pedicles and thus cannot be assumed to tolerate or require larger-diameter screws. (Journal of Surgical Orthopaedic Advances 27(1):33–38, 2018) Key words: cervical pedicle, femoral head, fusion, instrumentation, morphometry, pedicle dimensions, pedicle height, pedicle screw, pedicle size, pedicle width, screw fixation, thoracic pedicle

Pectoralis Major Tendon Insertion Anatomy and Description of a Novel Anatomic Reference - CPT Joseph H. Dannenbaum, MD; LT Michael D. Eckhoff, BS; MAJ Joseph W. Galvin, DO; CPT Betsey K. Bean, DO; MAJ David J. Wilson, MD; and COL(Ret) Edward D. Arrington, MD

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Pectoralis major rupture is an uncommon injury often treated surgically, requiring anatomic knowledge of the tendon insertion. This study defines the pectoralis major tendon insertion footprint and a novel anatomic relationship. Twelve cadaver shoulders were evaluated and measured using a standard surgical ruler to demonstrate the normal anatomic footprint. Measurements were taken from the anterior medial margin of the articular surface of the humeral head to the superior margin of the pectoralis major insertion and its relation to the latissimus dorsi tendon insertion. The average length and width of the pectoralis major insertion were 73.3 š 10.0 mm and 3.3 š 0.54 mm, respectively, consistent with previous publications. On average, the superior margin of the pectoralis tendon was within 1 mm of the latissimus dorsi insertion and 41.2 š 9.27 mm from the articular margin. These points form a new anatomic reference of the latissimus dorsi, providing an intraoperative reference point when performing pectoralis major muscle tendon repair. (Journal of Surgical Orthopaedic Advances 27(1):39–41, 2018) Key words: anatomic insertion, pectoralis major, pectoralis major repair, pectoralis major rupture

Effects of Accreditation Council for Graduate Medical Education Duty Hour Regulations on Clinical Preparedness of First-Year Orthopaedic Attendings: A Survey of Senior Orthopaedic Surgeons - Steven T. DiSegna, MD; Timothy D. Kelley, MD; Deborah M. DeMarco, MD; and Abhay R. Patel, MD

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It is unclear how the Accreditation Council for Graduate Medical Education (ACGME) resident duty hour restriction has affected attending orthopaedic surgeons in their first year of practice. The purpose of this study was to compare the clinical preparedness of first-year orthopaedic attending surgeons who trained with ACGME duty hour regulations versus those trained without regulations. Senior orthopaedic surgeons with greater than 10 years of experience were surveyed and results indicate that first-year attendings who trained with ACGME duty hour regulations required more supervision reviewing cases preoperatively, required more assistance completing operative cases, had inferior technical skills, had more major operative complications, had poorer physical exam skills, and delivered an inferior quality of care. Private attendings were most critical. In the postregulatory era, residency programs must optimize the resident’s time to ensure competency on graduation. Strategies include increasing midlevel staff, focusing on competencies outlined by ACGME milestones, and increasing the role of simulation. (Journal of Surgical Orthopaedic Advances 27(1):42–46, 2018) Key words: ACGME, duty hour regulation, orthopaedic surgery residency

Incidence and Risk Factors for Reoperation Following Meniscal Repair in a Military Population - CPT Alaina M. Brelin, MD; CPT Michael A. Donohue, MD; LCDR George C. Balazs, MD; LCDR Lance E. LeClere, MD; CDR John-Paul H. Rue, MD; and MAJ Jonathan F. Dickens, MD

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The purpose of this study is to determine the reoperation rate following meniscal repair and the associated risk factors. The Military Health System Data Repository was queried for active duty patients between January 2009 and December 2012 undergoing meniscal repair by Current Procedural Terminology code (29882, 29883, and 27403). This cohort was then screened for subsequent procedures following the index procedure. Risk factors for reoperation were calculated using a Cox proportional hazard analysis. A total of 3259 primary meniscal repairs were identified over the study period, of which 1423 (43.7%) were performed in conjunction with anterior cruciate ligament (ACL) reconstruction. The reoperation rate was 13.6%, occurring at a median of 1.1 years following the index procedure. Marine Corps service, younger age (<35), enlisted or cadet rank, and junior rank status were identified as significant risk factors for requiring reoperation. Isolated repairs were significantly more likely to require a secondary procedure than those with concomitant ACL reconstruction. Meniscal repairs performed in the military demonstrate similar reoperation rates as published literature despite increased occupational demands. (Journal of Surgical Orthopaedic Advances 27(1):47–51, 2018) Key words: failure, meniscus repair, meniscus tear, military, reoperation

Smartphone Photography as a Tool to Measure Knee Range of Motion - Megan Conti Mica, MD; Eric R. Wagner, MD; and Alexander Y. Shin, MD

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The objective of this study was to validate measuring knee range of motion (ROM) from smartphone photography. Thirty-two participants (64 knees) obtained smartphone photographs of knee flexion and extension. Surgeons obtained the same photographs and goniometric measurement of ROM. ROM was measured using Adobe Photoshop. Goniometer versus digital measurements, participant versus surgeon photographs, and interobserver measurements were analyzed. The average difference in goniometer and digital photograph measurements was 5°. The interclass correlation was .642(L) and .656(R). The Bland–Altman plots demonstrated that 29/32 digital measurements were within the 95% confidence interval (CI). Participants’ versus researchers’ photographs averaged a 2° difference. The interclass correlation was .924(L) and .91(R). Bland–Altman plots demonstrated that 31/32 measurements were within the 95% CI. Interobserver reliability averaged a ROM difference of 5°. The concordance coefficients were .647(L) and .723(R). Bland–Altman plots demonstrated that 30 of 32 digital measurements were within the 95% CI. Measuring knee ROM using smartphone digital photography is valid and reliable. (Journal of Surgical Orthopaedic Advances 27(1):52–57, 2018) Key words: digital photography, knee range of motion, smartphone

Pediatric Orthopaedic Consults From Chiropractic Care - Andy B. Awwad, BS; William L. Hennrikus, MD; and Douglas G. Armstrong, MD

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Alternative medicine in pediatrics is expanding, with chiropractic now a common choice for families seeking alternative medical care. Currently, there is sparse information in the literature exploring the role of chiropractic in orthopaedic pathology. The objective of this case series is to present pediatric patients who received treatment from chiropractors and orthopaedic physicians as well as to review the respective existing research. Data collected included chiropractic diagnosis, orthopaedic diagnosis, imaging studies, treatments, and complications. Twenty-three patients were studied. Scoliosis, LeggCalve-Perthes disease, developmental dysplasia of the hip, cerebral palsy, skeletal dysplasia, and slipped´ capital femoral epiphysis were diagnoses included. Children had multiple sessions of chiropractic for management of these conditions. The parents’ perception for chiropractic was positive in every case. Delayed referral, misdiagnosis, adverse events from manipulative therapy, and ineffective treatments were observed in the present study. More research is indicated to validate chiropractic in children with orthopaedic pathology. (Journal of Surgical Orthopaedic Advances 27(1):58–63, 2018) Key words: chiropractic, hip dysplasia, manipulative therapy, pediatric orthopaedic, Perthes, scoliosis

Hip Fracture Mortality: Differences Between Intertrochanteric and Femoral Neck Fractures - Nicholas B. Frisch, MD, MBA; Nolan Wessell, MD; Michael Charters, MD; Alexander Greenstein, BS; Jonathan Shaw, BS; Edward Peterson, PhD; and S. Trent Guthrie, MD

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The purpose of this study was to identify the specific risk factors that affect mortality in patients with hip fractures and differentiate mortality-associated factors between intertrochanteric (IT) and femoral neck (FN) fractures. A total of 1538 consecutive patients with hip fractures were treated at the authors’ institution between January 2005 and October 2013. Ultimately 858 IT and 479 FN fracture patients were included on the basis of age >60 years with an isolated hip fracture. Mortality rate at 90 days was 12.1% for IT and 9.6% for FN fractures. In both IT and FN fractures, variables associated with mortality risk include increased age, greater days to surgery, male gender, decreased body mass index, and increased American Society of Anesthesiologists score. When evaluated independently, the presence of cardiac arrhythmia and chronic kidney disease was strongly associated with greater mortality risk in FN fracture patients. The presence of chronic kidney disease and hypertension correlated with decreased mortality risk among FN fracture patients. (Journal of Surgical Orthopaedic Advances 27(1):64–71, 2018) Key words: femoral neck, hip fractures, intertrochanteric, mortality

Readability of Patient Educational Materials for Total Hip and Knee Arthroplasty -  Asa W. Shnaekel, MD, MPH; Kristie B. Hadden, PhD; Tina D. Moore, EdD; Latrina Y. Prince, EdD; and C. Lowry Barnes, MD

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This study aimed to evaluate patient education materials that are focused on total hip arthroplasty (THA) and total knee arthroplasty (TKA) using health literacy best practices and plain language principles as frameworks. Readability assessments were conducted on a sample of nine patient education documents that are commonly given to THA and TKA surgery patients. Mean readability scores were compared across the sample. The mean readability grade level for the nine arthroplasty educational documents analyzed in this study was 11th grade (10.5). The mean readability ranged from 9th to 12th grade. The documents in this study were written at levels that exceed recommendations by health literacy experts. Health literacy best practices and plain language principles were suggested to reduce the demands on patients so that the documents are easier to understand. Incorporating health literacy best practices into patient education materials for THA and TKA can contribute to improved communication with patients that is necessary for patient understanding and satisfaction. (Journal of Surgical Orthopaedic Advances 27(1):72–76, 2018) Key words: health literacy, hip arthroplasty, knee arthroplasty, patient education, readability

Friction Syndromes of the Knee: The Iliotibial Band and Anterior Fat Pads - Robert D. Wissman, MD, and Stephen J. Pomeranz, MD

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As participation in sporting activities increases among the general population, the incidence of overuse injuries continues to rise. Friction syndromes of the knee are common and are often clinically diagnosed without the need for imaging. However, clinical symptoms may overlap with other joint abnormalities, and physical examination may be limited in individuals with excessive pain. Magnetic resonance imaging has remained the modality of choice for the evaluation of internal derangements of the joints and is a useful aid in the diagnosis of friction syndrome of the knee. This case report provides clinicians with an understanding of the most common friction syndromes of the knee joint as well as their imaging findings. (Journal of Surgical Orthopaedic Advances 27(1):77–80, 2018) Key words: fat pad, friction syndrome, iliotibial band syndrome, knee, magnetic resonance imaging

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